反応 #2358561

反応方程式

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

hydroxylamine hydrochloride

→

title compound

収率 85.3%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-9-hydroxyimino-10-methyl-(9H,10H)-acridine

収率 85.3%

溶媒

pyridine

反応条件

後処理

1. 1
   その他Solvent was removed
2. 2
   workup.ADDITIONthe residue was treated with water
3. 3
   その他to remove excess of hydroxylamine
4. 4
   その他Crude material was crystallized from methanol-water

実験手順

To a solution of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione (290 mg, 0.5 mmole) in pyridine (5 mL) was added hydroxylamine hydrochloride (210 mg, 30 mmole) and the mixture was stirred at 100° C. for 8 hrs. Solvent was removed and the residue was treated with water to remove excess of hydroxylamine. Crude material was crystallized from methanol-water to give 245 mg (85%) of the title compound. MS 575 (MH+).

出典