反応 #2358559

反応方程式

10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride

3,5-dimethylpiperidine

→

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridin-9(10H)-one

溶媒

THF

反応条件

後処理

1. 1
   その他Solvent was evaporated
2. 2
   workup.ADDITIONthe residue was treated with 1 N HCl (50 mL)
3. 3
   workup.STIRRINGstirred for 10 minutes
4. 4
   ろ過Yellow product was collected by filtration
5. 5
   洗浄washed with water and methanol
6. 6
   その他dried
7. 7
   その他Crude material was crystallized from chloroform-ethanol
8. 8
   その他to provide 900 mg (80%) of yellow 11-4

実験手順

To a solution of 10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride from Example 7 (810 mg, 2 mmole) in THF (20 mL) was added 3,5-dimethylpiperidine (2 mL, 15 mmole) and the reaction mixture was stirred at room temperature for 6 hours. Solvent was evaporated and the residue was treated with 1 N HCl (50 mL) and stirred for 10 minutes. Yellow product was collected by filtration, washed with water and methanol and dried. Crude material was crystallized from chloroform-ethanol to provide 900 mg (80%) of yellow 11-4. MS 560 (MH+).

出典