反応 #2358550

反応方程式

Mixture ( 6 )

dibenzyl 5-(benzyloxy)-4-(5-hydroxy-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-yl)-2-isopropylphenyl phosphate

→

Compound 2

収率 81.0%

5-hydroxy-4-(5-hydroxy-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-yl)-2-isopropylphenyl dihydrogen phosphate

収率 81.0%

溶媒

MeOH

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   その他for 2 hr
3. 3
   ろ過Pd/C was filtered off through a pad of celite
4. 4
   濃縮the mother liquid was concentrated

実験手順

Mixture (6) (2.3 g) was hydrogenated in MeOH (50 mL) using Pd/C (10%, dry, 200 mg) and H2 balloon at 1 atm at room temperature for 2 hr. Pd/C was filtered off through a pad of celite and the mother liquid was concentrated to give Compound 2 as white solid (1.13 g, 81%).

出典