反応 #2358549

反応方程式

compound ( 4 )

5-(2-(benzyloxy)-5-isopropyl-4-(methoxymethoxy)phenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol

HCl

→

5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride

収率 74.0%

溶媒

MeOH

反応条件

後処理

1. 1
   温度cooled
2. 2
   その他The white precipitate thus obtained
3. 3
   ろ過was filtered
4. 4
   洗浄washed with ether (2×20 ml)

実験手順

To the solution of compound (4) (2.10 g, 3.95 mmol) in MeOH (100 ml), HCl (2 ml, 2N) was added, and then the resultant mixture was heated at 65° C. for 5 h, then cooled. The white precipitate thus obtained was filtered, washed with ether (2×20 ml) gave 1.53 g (74%) of 5-(2-(benzyloxy)-4-hydroxy-5-isopropylphenyl)-4-(6-morpholinopyridin-3-yl)-4H-1,2,4-triazol-3-ol hydrochloride (5).

出典