反応 #2358548

反応方程式

8

dibenzyl 4-(4-(2,3-dihydro-1H-inden-5-yl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-5-hydroxy-2-isopropylphenyl phosphate

→

phosphate

収率 86.9%

4-(4-(2,3-dihydro-1H-inden-5-yl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-5-hydroxy-2-isopropylphenyl dihydrogen phosphate

収率 86.9%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   workup.ADDITIONthe crude product was reslurried in 98:2 mixture of diethylether

実験手順

A solution of 0.15 g (0.24 mmols) of 8 and 25 mg of Pd—C catalyst in 20 mL of anhydrous ethanol was subjected to hydrogenation conditions at 1 atm pressure for 2 h. The catalyst was filtered off and the crude product was reslurried in 98:2 mixture of diethylether:ethanol to afford 90 mg of the phosphate 9 as off white solid.

出典