反応 #2358543

反応方程式

(S)-3-((R)-1-hydroxy-2-methylpropyl)pyrrolidine-1-carboxylic acid t-butyl ester

p-chlorophenol

Diisopropyl azodicarboxylate

triphenylphosphine

→

(S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine-1-carboxylic acid t-butyl ester

収率 10.8%

溶媒

—

Hexanes

—

hexanes

2-methyl-tetrahydrofuran

反応条件

後処理

1. 1
   その他the vessel purged with nitrogen
2. 2
   workup.STIRRINGthe resulting mixture was stirred at room temperature for 30 minutes
3. 3
   その他The phases were separated
4. 4
   洗浄the organic layer was washed with 1.0 M NaOH in water (600 mL)
5. 5
   洗浄washed with diluted saturated aqueous NaCl (20 mL)
6. 6
   乾燥dried over Na2SO4
7. 7
   その他to yield the crude BOC-
8. 8
   workup.STIRRINGthe resulting mixture was stirred for 30 minutes
9. 9
   ろ過Solids were filtered off
10. 10
    その他to yield the crude BOC-
11. 11
    その他was then purified by silica gel chromatography (0-10-20% EtOAc in hexanes)

実験手順

(S)-3-((R)-1-hydroxy-2-methylpropyl)pyrrolidine-1-carboxylic acid t-butyl ester (35.0 g, 144 mmol, 1.0 eq.), triphenylphosphine (41.5 g, 158 mmol, 1.1 eq.), p-chlorophenol (37.0 g, 288 mmol, 2.0 eq.) and 2-methyl-tetrahydrofuran (300 mL) were combined and the vessel purged with nitrogen. Diisopropyl azodicarboxylate (31.2 mL, 1.1 eq.) was added slowly at room temperature over 2 hours. The mixture was then stirred at room temperature overnight. Hexanes (600 mL) were added and the resulting mixture was stirred at room temperature for 30 minutes. The phases were separated and the organic layer was washed with 1.0 M NaOH in water (600 mL), washed with diluted saturated aqueous NaCl (20 mL), then dried over Na2SO4 to yield the crude BOC-protected intermediate. Additional hexanes (50 mL) were added and the resulting mixture was stirred for 30 minutes. Solids were filtered off to yield the crude BOC-protected intermediate as a thick oil, which was then purified by silica gel chromatography (0-10-20% EtOAc in hexanes) to yield (S)-3-[(S)-1-(4-chlorophenoxy)-2-methylpropyl]pyrrolidine-1-carboxylic acid t-butyl ester (5.5 g).

出典