反応 #2358534

反応方程式

HCl

3-(5-Dimethylcarbamoyl-pent-ynyl)benzoic acid ethyl ester

sodium hydroxide

→

3-(5-dimethylcarbamoyl-pent-1-ynyl)-benzoic acid

収率 74.0%

3-(5-Dimethylcarbamoyl-pent-1-ynyl)-benzoic acid

収率 74.0%

反応条件

後処理

1. 1
   その他the solvent was removed under vacuum
2. 2
   その他The residue was triturated with ethyl acetate

実験手順

3-(5-Dimethylcarbamoyl-pent-ynyl)benzoic acid ethyl ester (0.800 g, 2.78 mmol) was treated with sodium hydroxide 1M solution (6 mL) overnight. To the reaction mixture 7 mL of HCl 1M solution was added and the solvent was removed under vacuum. The residue was triturated with ethyl acetate, to give 3-(5-dimethylcarbamoyl-pent-1-ynyl)-benzoic acid (24) (0.590 g, 2.05 mmol; yield 74%) as white off powder.

出典