反応 #2358525

反応方程式

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

HCl

NaOH

→

title compound

収率 78.6%

2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethanamine

収率 78.6%

溶媒

EtOH

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate (2×100 ml)
2. 2
   洗浄The combined organic phase was washed with brine (75 ml)
3. 3
   乾燥dried (Na2SO4)
4. 4
   その他evaporated

実験手順

A mixture of tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate (1.4 g, 4.2 mmol) in EtOH (18 ml) was added HCl (1.25 M in EtOH, 6 ml). The mixture was stirred at ambient temperature for 20 h. The aqueous phase was made basic by addition of aqueous NaOH (1 M, 50 ml) and extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with brine (75 ml), dried (Na2SO4) and evaporated to yield the title compound (0.77 g, 77%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

出典