反応 #2358524

反応方程式

1.2-dibromoethane

boc-glycinol

N2

DEAD

3-fluoro-5-methylsulfonyl-phenol

triphenylphosphine

→

title compound

収率 70.0%

tert-butyl 2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl-carbamate

収率 70.0%

溶媒

EtOAc

water

THF

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   抽出The aqueous phase was extracted with ethyl acetate (2×100 ml)
3. 3
   洗浄The combined organic phase was washed with aqueous NaOH (3 M, 50 ml) and brine (75 ml)
4. 4
   乾燥dried (Na2SO4)
5. 5
   その他evaporated
6. 6
   その他Purification by flash column chromatography (ethyl acetate/isooctane, 0:1 to 1:0)

実験手順

A mixture of triphenylphosphine (1.9 g, 7.3 mmol) in dry THF (20 ml) was flushed with N2(g) and DEAD (3.1 ml, 6.9 mmol) was added drop-wise, 1.2-dibromoethane followed by 3-fluoro-5-methylsulfonyl-phenol (1.1 g, 6.1 mmol) and then boc-glycinol (1.0 ml, 6.1 mmol) in portions. The mixture was stirred at 70° C. for 20 h, cooled to room temperature and water and EtOAc was added. The aqueous phase was extracted with ethyl acetate (2×100 ml). The combined organic phase was washed with aqueous NaOH (3 M, 50 ml) and brine (75 ml), dried (Na2SO4) and evaporated. Purification by flash column chromatography (ethyl acetate/isooctane, 0:1 to 1:0) gave the title compound (1.4 g, 70%). MS m/z (relative intensity, 70 eV 298 (M+, 18), 296 (M+, 18), 109 (bp), 107 (99), 82 (15).

出典