反応 #2358516

反応方程式

1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene

di-ethylamine

→

title compound

収率 61.7%

N,N-diethyl-2-(3-fluoro-5-methylsulfonyl-phenoxy)ethanamine

収率 61.7%

溶媒

ethanol

反応条件

後処理

1. 1
   その他Preparation
2. 2
   その他Purification by flash column chromatography (ethyl acetate/methanol, 1:0 to 1:1)

実験手順

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.5 g, 1.68 mmol) and di-ethylamine (1.39 ml, 13.46 mmol) in ethanol (4 ml). Purification by flash column chromatography (ethyl acetate/methanol, 1:0 to 1:1) gave the title compound (300 mg, 61.6%). The amine was converted to the hydrochloric acid salt and re-crystallized from methanol/diethyl ether: M.p. 172.3° C. MS m/z (relative intensity, 70 eV) 289 (M+, 1), 274 (6), 87 (6), 86 (bp), 58 (5).

出典