反応 #2358508

反応方程式

hydrochloric acid

1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene

butan-1-amine

→

N-[2-(3-fluoro-5-methylsulfonyl-phenoxy)ethyl]butan-1-amine

溶媒

ethanol

反応条件

後処理

1. 1
   その他Preparation
2. 2
   その他re-crystallized from ethanol/diethyl ether

実験手順

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-fluoro-5-methylsulfonyl-benzene (0.3 g, 1.01 mmol) and butan-1-amine 0.61 ml, 0.5907 mmol) in ethanol (4 ml). Yield: 290 mg (99%). The amine was converted to the hydrochloric acid salt and re-crystallized from ethanol/diethyl ether: M.p. 204° C. MS m/z (relative intensity, 70 eV) 289 (M+, 1), 246 (35), 86 (bp), 56 (12), 87 (12).

出典