反応 #2358499

ord-93119d74154f46c3a6e359a34f56ebb6

反応方程式

COC(=O)C(c1ccccc1)C1CCCCN1.Cl
methylphenidate HCl
COC(=O)C(c1ccccc1)C1CCCCN1
Methylphenidate

試薬

なし

溶媒

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The wet pellets are dried (Fluid Air Model#0050)
  2. 2
    ろ過sieved (30 mesh<Acceptable<20 mesh)

実験手順

In a preferred manufacturing process, methylphenidate HCl and microcrystalline cellulose (Avicel PH-101) are blended in a Hobart Mixer. Purified water is added to the dry mixture and the wet granulation is extruded (MG-55 Multi granulator). The extrudate is then spheronized into pellets (Caleva Model#SPH250). The wet pellets are dried (Fluid Air Model#0050) and sieved (30 mesh<Acceptable<20 mesh).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09119809B2uspto-grants-2015_09