反応 #2348125

反応方程式

3-methoxythioanisole

oxone

acetone

→

1-methanesulfonyl-3-methoxy benzene

収率 98.0%

溶媒

water

反応条件

後処理

1. 1
   その他resulting in the formation of a white precipitate
2. 2
   ろ過the solid was filtered off
3. 3
   洗浄washed with acetone
4. 4
   濃縮Filtrate was concentrated
5. 5
   その他to remove acetone
6. 6
   抽出Aqueous layer was extracted with EtOAc (2×200 mL)
7. 7
   乾燥dried over Na2SO4
8. 8
   その他The solvent was removed

実験手順

To a solution of 3-methoxythioanisole (3.084 g, 20 mmol) in 300 mL acetone was added a solution of oxone (30.74 g, 50 mmol) in 125 mL water, resulting in the formation of a white precipitate. Stirring continued overnight, and the solid was filtered off and washed with acetone. Filtrate was concentrated to remove acetone. Aqueous layer was extracted with EtOAc (2×200 mL) and dried over Na2SO4. The solvent was removed to give 1-methanesulfonyl-3-methoxy benzene (3.68 g, 98%) as oil.

出典