反応 #2348121

反応方程式

(4-Methoxybenzyl)triphenylphosphonium chloride

Sodium methoxide

Pyridinecarbaldehyde

→

trans-stilbene

収率 61.8%

溶媒

methanol

反応条件

後処理

1. 1
   workup.WAITthe stirring was continued at room temperature overnight
2. 2
   その他Excess of sodium methoxide was quenched by addition of water and pH of the reaction mixture
3. 3
   workup.ADDITIONto pH=7.5-8.0 by addition of saturated sodium bicarbonate
4. 4
   抽出Products were then extracted with ethyl acetate (500 mL)
5. 5
   洗浄Combined extracts were washed with water and brine
6. 6
   濃縮concentrated in vacuo
7. 7
   その他The crude product was purified by column chromatography

実験手順

(4-Methoxybenzyl)triphenylphosphonium chloride (4.79 g, 11.4 mmol) was suspended in 50 mL of dry methanol. Sodium methoxide (4.94 g of 25% solution in methanol, 22.8 mmol) was added in one portion to the above suspension and the resulting mixture was stirred at room temperature under nitrogen for 30 minutes. Pyridinecarbaldehyde (1.57 g, 11.4 mmol) was then added and the stirring was continued at room temperature overnight. Excess of sodium methoxide was quenched by addition of water and pH of the reaction mixture was adjusted to pH=4.5 with 1 N HCl, and then to pH=7.5-8.0 by addition of saturated sodium bicarbonate. Products were then extracted with ethyl acetate (500 mL). Combined extracts were washed with water and brine, and concentrated in vacuo. The crude product was purified by column chromatography using ethyl acetate in hexane (5%-10%) to give 1.27 g (46%) of trans-stilbene.

出典