反応 #2348116

反応方程式

1-(2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one

ethyl diisopropylamine

L-Cystein methyl ester hydrochloride

→

title compound

収率 82.0%

Methyl 2-(4-oxo-4-(2,6,6-trimethylcyclohex-3-enyl)butan-2-ylamino)-3-(4-oxo-4-(2,6,6-trimethylcyclohex-3-enyl)butan-2-ylthio)propanoate

収率 82.0%

溶媒

MeOH

反応条件

後処理

1. 1
   温度to reflux during 28 h
2. 2
   その他The solvent is removed in vacuo
3. 3
   workup.DISSOLUTIONthe residue dissolved in methyl t-butyl ether
4. 4
   洗浄The solution is washed with dilute aq. NaCl
5. 5
   乾燥dried over MgSO4
6. 6
   濃縮concentrated
7. 7
   その他The residue is purified by chromatography on SiO2

実験手順

A solution of 1-(2,6,6-trimethylcyclohex-3-enyl)but-2-en-1-one (19.28 g, 100 mmol, 2 equiv.), ethyl diisopropylamine (6.45 g, 50 mmol, 1 equiv.) and L-Cystein methyl ester hydrochloride (8.60 g, 50 mmol, 1 equiv.) in MeOH (120 ml) is heated to reflux during 28 h. The solvent is removed in vacuo and the residue dissolved in methyl t-butyl ether. The solution is washed with dilute aq. NaCl, dried over MgSO4 and concentrated. The residue is purified by chromatography on SiO2 to yield 21.3 g (82%) of the title compound as yellowish, viscous oil.

出典