反応 #2348102

反応方程式

hydrogen

compound ( 24 )

2-(4-propylphenyl)ethenyl-2,3-difluoro-4-(4-pentylphenyl)toluene

→

2-(4-propylphenyl)ethyl-2,3-difluoro-4-(4-pentylphenyl)toluene

収率 60.3%

溶媒

toluene

反応条件

後処理

1. 1
   その他was not absorbed
2. 2
   その他Pd/C was removed by filtration
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   その他The residue was purified by silica gel column chromatography and recrystallization

実験手順

0.33 g of Pd/C was added to 6.50 g of the compound (24) having been dissolved in 100 mL of toluene and 100 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed by filtration, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 3.94 g of 2-(4-propylphenyl)ethyl-2,3-difluoro-4-(4-pentylphenyl)toluene (Compound 1-2-3-3) as colorless crystals.

出典