反応 #2348099

反応方程式

hydrogen

compound ( 20 )

2-(2-(4-(4-propylphenyl)phenyl)ethenyl)-2,3-difluoro-4-ethoxytoluene

→

2-(2-(4-(4-propylphenyl)phenyl) ethyl)-2,3-difluoro-4-ethoxytoluene

収率 81.9%

溶媒

toluene

反応条件

後処理

1. 1
   その他was not absorbed
2. 2
   その他Pd/C was removed by filtration
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   その他The residue was purified by silica gel column chromatography and recrystallization

実験手順

0.36 g of Pd/C was added to 7.29 g of the compound (20) having been dissolved in 100 mL of toluene and 100 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed by filtration, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 6.00 g of 2-(2-(4-(4-propylphenyl)phenyl) ethyl)-2,3-difluoro-4-ethoxytoluene (Compound 1-3-3-22) as colorless crystals.

出典