反応 #2348097

反応方程式

hydrogen

compound 1-3-3-10

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-pentylcyclohexyl)cyclohexyl)ethene

→

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-pentylcyclohexyl)cyclohexyl)ethane

収率 50.1%

溶媒

toluene

反応条件

後処理

1. 1
   その他was not absorbed
2. 2
   その他Pd/C was removed
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   その他The residue was purified by silica gel column chromatography and recrystallization

実験手順

0.08 g of Pd/C was added to 1.65 g of the compound 1-3-3-10 having been dissolved in 12.5 mL of toluene and 12.5 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 0.83 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-(4-pentylcyclohexyl)cyclohexyl)ethane (Compound 1-3-3-2) as colorless crystals.

出典