反応 #2348093

反応方程式

hydrogen

compound 1-1-3-18

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-pentylcyclohexyl)ethene

→

1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-pentylcyclohexyl)ethane

収率 27.4%

溶媒

toluene

反応条件

後処理

1. 1
   その他was not absorbed
2. 2
   その他Pd/C was removed
3. 3
   workup.DISTILLATIONthe solvent was distilled off
4. 4
   その他The residue was purified by silica gel column chromatography and recrystallization

実験手順

0.27 g of Pd/C was added to 6.53 g of the compound 1-1-3-18 having been dissolved in 50 mL of toluene and 50 mL of Solmix, and under a hydrogen atmosphere, the mixture was stirred at room temperature until hydrogen was not absorbed. Pd/C was removed, and the solvent was distilled off. The residue was purified by silica gel column chromatography and recrystallization to obtain 1.8 g of 1-(2,3-difluoro-4-ethoxy-6-methylphenyl)-2-(4-pentylcyclohexyl)ethane (Compound 1-1-3-5) as colorless crystals.

出典