反応 #2347

反応方程式

sodium carbonate

hydrogen bromide

3-benzylbutyrolactone

ethanol

water

→

ethyl 4-benzyl-3-bromobutyrate

反応条件

後処理

1. 1
   抽出The mixture was extracted with ethyl acetate
2. 2
   その他the organic layer filterd through phase separating paper
3. 3
   その他evaporated

実験手順

A solution of RS 3-benzylbutyrolactone (1.14 g) in ethanol (20 ml) was stirred at 5° C. and gassed for 4 hours with a slow stream of hydrogen bromide. The solution was kept at 5° C. for 20 hours and water (70 ml) added followed by sodium carbonate to neutralise the acid. The mixture was extracted with ethyl acetate and the organic layer filterd through phase separating paper and evaporated to give ethyl 4-benzyl-3-bromobutyrate as an oil; NMR(CDCl3) δ 7.24(5H,m), 4.13(2H,q); 3.45(2H,m), 2.62(2H,d), 2.44(3H,m), 1.25(3H,t); m/e 285(M+H)+.

出典