反応 #2345326

反応方程式

methyl 16-hydroxyhexadecanoate

p-toluenesulfonic acid

NaHCO3

→

methyl 16-(2-tetrahydropyranyloxy)hexadecanoate

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他equipped with a stirrer and a dropping funnel
2. 2
   workup.ADDITION32.39 g (0.385 mol) of dihydropyan was dropped
3. 3
   workup.ADDITIONAfter the completion of the addition
4. 4
   workup.STIRRINGthe mixture was stirred at room temperature for additional 1 hour
5. 5
   その他the reaction
6. 6
   ろ過filtered
7. 7
   workup.DISTILLATIONAfter distilling off the solvent

実験手順

100.26 g (0.35 mol) of methyl 16-hydroxyhexadecanoate, 0.60 g (3.5 mol) of p-toluenesulfonic acid and 350 ml of dichloromethane were introduced into a 1-1 flask equipped with a stirrer and a dropping funnel and 32.39 g (0.385 mol) of dihydropyan was dropped thereto under stirring at 0° C. After the completion of the addition, the mixture was stirred at room temperature for additional 1 hour to thereby complete the reaction. Next, the reaction mixture was neutralized by adding 0.59 g (7 mmol) of NaHCO3 and filtered. After distilling off the solvent, crude methyl 16-(2-tetrahydropyranyloxy)hexadecanoate (III-a) was obtained.

出典