反応 #2339837

反応方程式

2-Phenylpiperidine

2,4-dichloropyrimidine

sodium bicarbonate

→

title compound

収率 66.0%

2-Chloro-4-(2-phenyl-piperidin-1-yl)-pyrimidine

収率 66.0%

溶媒

EtOH

反応条件

後処理

1. 1
   ろ過The mixture was filtered
2. 2
   その他the filtrate evaporated in vacuo
3. 3
   その他to give a yellow oil
4. 4
   その他The oil was purified by flash chromatography (EtOAc and isohexane (1:3)/silica)

実験手順

2-Phenylpiperidine, Intermediate 15, (0.5 g, 2.52 mmol), 2,4-dichloropyrimidine (0.41 g, 2.77 mmol) and sodium bicarbonate (0.59 g, 5.55 mmol) in dry EtOH (10 mL) were refluxed for 2 hours, under an atmosphere of nitrogen. The mixture was filtered and the filtrate evaporated in vacuo to give a yellow oil. The oil was purified by flash chromatography (EtOAc and isohexane (1:3)/silica) to give the title compound as a colourless oil (46 g, 66%).

出典