反応 #2339836

反応方程式

2-Phenylpyridine

HCl

sodium hydroxide

→

title compound

2-Phenylpiperidine

溶媒

EtOH

反応条件

後処理

1. 1
   その他After removal of the catalyst
2. 2
   ろ過by filtration
3. 3
   その他the solution was evaporated in vacuo to a pale yellow HCl salt of the product
4. 4
   その他The free base is obtained
5. 5
   抽出The aqueous is then extracted with Et2O several times
6. 6
   乾燥the extracts dried (MgSO4)
7. 7
   その他evaporated to an oil

実験手順

2-Phenylpyridine, Intermediate 14, (4.0 g, 25.81 mmol), and concentrated HCl (3 mL) in EtOH (15 mL) were treated with platinum oxide and subjected to catalytic hydrogenation (˜1 atm, balloon), at room temperature for 72 hours. After removal of the catalyst by filtration, the solution was evaporated in vacuo to a pale yellow HCl salt of the product. The free base is obtained by treating the residue with 10% aqueous sodium hydroxide. The aqueous is then extracted with Et2O several times and the extracts dried (MgSO4) and evaporated to an oil to give the title compound.

出典