反応 #2336533

反応方程式

2-Methylthiophenol

potassium carbonate

DMF

→

title compound

収率 42.0%

3,6-Bis(2′-methylphenylthio) phthalonitrile

収率 42.0%

反応条件

後処理

1. 1
   その他The mixture was isolated
2. 2
   その他to give a yellow oil
3. 3
   その他The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane)

実験手順

2-Methylthiophenol (10.60 g, 85.5 mmol), potassium carbonate (11.82 g, 82.0 mmol) and ditosylated dicyanohydroquinone (20.00 g, 42.7 mmol) in DMF (75 mL) were reacted as described above. The mixture was isolated as described above to give a yellow oil. The material was purified by flash column chromatography (eluting 10% ethyl acetate:isohexane) to give the title compound as a yellow solid (8.85 g, 23.8 mmol, 42%). [Found: C, 70.7%; H, 4.6%; N, 7.5%; S, 17.2%; C22H16N2S2 requires C, 70.9%; H, 4.3%; N, 7.5%; S, 17.2%]; MS (EI+) 372 (M+, 100%), 357 (M-CH3, 8), 339 (20).

出典