反応 #2336525

反応方程式

triethylamine

oxalyl chloride

DMSO

1-(4-methylbenzyl)-4-piperidinol

1-(4-methylbenzyl)-4-hydroxypiperidine

ammonium chloride

→

1-(4-methylbenzyl)-4-piperidinone

収率 81.0%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   その他to come to room temperature
2. 2
   洗浄The organic phase was washed with water and brine
3. 3
   その他dried
4. 4
   その他evaporated

実験手順

To 2.8 mL (32 mmol) of oxalyl chloride in 75 mL of CH2Cl2 at −78° C. was added 4.6 mL (64 mmol) of DMSO. To this mixture was added 5.3 g (26 mmol) of 1-(4-methylbenzyl)-4-piperidinol 123 in 10 mL of CH2Cl2, and the mixture was stirred 5 min in the cold. The mixture was quenched with 18 mL (129 mmol) of triethylamine and allowed to come to room temperature, and saturated aqueous ammonium chloride was added. The organic phase was washed with water and brine, dried, and evaporated to give 4.27 g (81%) of 1-(4-methylbenzyl)-4-piperidinone (124), which was used as is without further purification. GC/MS showed 100% purity with a molecular ion of 203.

出典