反応 #2336521

反応方程式

Sodium acetate

7-furyl-3-methyl-4-chromanone

hydroxylamine hydrochloride

→

7-furyl-3-methyl-4-chromanone oxime

溶媒

methanol

反応条件

後処理

1. 1
   その他The reaction was quenched with H2O
2. 2
   抽出extracted with ether (2×25 mL)
3. 3
   乾燥The combined organic layers were dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

Sodium acetate (395 mg, 4.82 mmol) was added portionwise to a solution of 7-furyl-3-methyl-4-chromanone (60) (500 mg, 2.19 mmol) and hydroxylamine hydrochloride (167 mg, 2.41 mmol) in methanol (5 mL), and stirred overnight at room temperature. The reaction was quenched with H2O and extracted with ether (2×25 mL). The combined organic layers were dried over MgSO4, filtered and concentrated to give 7-furyl-3-methyl-4-chromanone oxime (61) as a white solid, m.p. 175-177° C.

出典