反応 #2336519

反応方程式

Ethyl 5-benzyloxy-1-methylpyrazole-4-carboxylate

LiOH.H2O

water

→

5-benzyloxy-1-methyl-4-carboxylic acid

収率 90.3%

5-BENZYLOXY-1-METHYLPYRAZOLE-4-CARBOXYLIC ACID

収率 90.3%

溶媒

THF

MeOH

反応条件

実験手順

Ethyl 5-benzyloxy-1-methylpyrazole-4-carboxylate (755 mg, 2.9 mmol) was likewise hydrolyzed using LiOH.H2O (243 mg, 5.8 mmol) in THF (20 mL), MeOH (4 mL), and water (10 mL), to afford 608 mg of 5-benzyloxy-1-methyl-4-carboxylic acid (25) as a white solid, m.p. 117-122° C.

出典