反応 #2336517

反応方程式

methyl 3-benzyloxypicolinate

3-chloroperoxybenzoic acid

→

methyl 3-benzyloxypicolinate-1-oxide

収率 94.6%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   抽出The reaction mixture was then extracted with 5% sodium bisulfite solution (100 mL)
2. 2
   乾燥After drying (MgSO4)
3. 3
   その他the solvent was evaporated

実験手順

A solution of methyl 3-benzyloxypicolinate (4.86 g) and 3-chloroperoxybenzoic acid (5.75 g, 60% peracid) in CH2Cl2 (100 mL) was stirred at room temperature for 40 hours. The reaction mixture was then extracted with 5% sodium bisulfite solution (100 mL) then with 0.5N NaOH solution (150 mL). After drying (MgSO4), the solvent was evaporated to give 4.9 g of methyl 3-benzyloxypicolinate-1-oxide as a white solid. Recrystallization from methylcyclohexane/toluene gave a crystalline solid, m.p. 104-106° C.

出典