反応 #2329044

反応方程式

4-methoxy-benzoyl chloride

(4-chloro-phthalazin-1-yl)-hydrazine

compound C1

(4-chloro-phthalazin-1-yl)-hydrazine

→

title compound

収率 54.3%

6-Chloro-3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazine

収率 54.3%

溶媒

toluene

toluene

triethylamine

反応条件

後処理

1. 1
   温度cooled to ambient temperature
2. 2
   ろ過filtered with suction
3. 3
   洗浄rinsed with toluene
4. 4
   その他The solid is recrystallized from N,N-dimethylformamide
5. 5
   洗浄the precipitate is washed with water
6. 6
   その他dried

実験手順

6.0 g (4-chloro-phthalazin-1-yl)-hydrazine (compound C1) are suspended in a mixture of 160 ml toluene and 18 ml triethylamine at 60° C. and treated with a solution of 6.0 g 4-methoxy-benzoyl chloride in 48 ml toluene. The mixture is stirred at 110° C. for 6 h, cooled to ambient temperature, filtered with suction and rinsed with toluene. The solid is recrystallized from N,N-dimethylformamide, the precipitate is washed with water and dried to yield 5.2 g of the title compound (m.p.: 192-193° C.).

出典