反応 #2329033

反応方程式

CH2Cl2

methyl-4-hydroxybenzoate

K2CO3

bromododecane

→

title compound

収率 95.0%

Methyl 4-dodecyloxybenzoate

収率 95.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他Reaction
2. 2
   温度was cooled to room temperature
3. 3
   その他precipitated into cold water
4. 4
   ろ過The precipitate was collected by suction filtration
5. 5
   その他purified by re-crystallization from acetone

実験手順

To a thoroughly degassed suspension of K2CO3 (127 g, 921 mmol) in DMF (600 mL) was added methyl-4-hydroxybenzoate (70 g, 461 mmol) and the mixture heated to 70° C. after which was added bromododecane (126 g, 507 mmol) and the reaction allowed to stir at 70° C. under argon for 3 hours, after which TLC (CH2Cl2) showed completion. Reaction was cooled to room temperature and precipitated into cold water. The precipitate was collected by suction filtration and purified by re-crystallization from acetone to give the title compound (140 g, 95%).

出典