反応 #2329031

反応方程式

water

cytosine

diphenylacetyl chloride

→

N4-(Diphenyl acetyl)cytosine

溶媒

pyridine

反応条件

後処理

1. 1
   workup.ADDITIONwere added in portions
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature overnight
3. 3
   その他the end of the reaction
4. 4
   その他the solvent was evaporated under reduced pressure
5. 5
   workup.ADDITION100 ml of water were added to the residue
6. 6
   workup.STIRRINGthe mixture was stirred vigorously for 30 minutes
7. 7
   ろ過filtered
8. 8
   洗浄The white precipitate was washed with 100 ml of ether
9. 9
   その他dried

実験手順

To stirred suspension of (3 gr, 27 mmol) of cytosine (C) in 30 ml of dry pyridine at room temperature (6.85 g, 29.7 mmol) of diphenylacetyl chloride were added in portions. The reaction mixture was stirred at room temperature overnight. TLC indicated the end of the reaction. 2 ml of water was added and the solvent was evaporated under reduced pressure. 100 ml of water were added to the residue and the mixture was stirred vigorously for 30 minutes. The desired product (11) was precipitate and filtered. The white precipitate was washed with 100 ml of ether and dried.

出典