反応 #2329011

反応方程式

1,3-Cyclohexanediol

acetonitrile

potassium fluoride on alumina

4-fluoro-2-chloro-benzonitrile

→

title compound

収率 8.7%

2-Chloro-4-(3-hydroxy-cyclohexyloxy)-benzonitrile

収率 8.7%

溶媒

Diethyl ether

反応条件

後処理

1. 1
   その他dried round bottom flask under nitrogen
2. 2
   温度heated
3. 3
   温度at reflux for 16 h
4. 4
   抽出was then extracted with water (2×)
5. 5
   乾燥dried (MgSO4)
6. 6
   濃縮concentrated
7. 7
   その他Purification
8. 8
   洗浄eluting with 10% EtOAc/hex (ethylacetate and hexane)

実験手順

1,3-Cyclohexanediol (116 mg, 1.0 mmole) was added to a flame dried round bottom flask under nitrogen. The flask was then charged with 5 mL of dry acetonitrile, 26 mg of potassium fluoride on alumina (0.1 mmol), and 4-fluoro-2-chloro-benzonitrile (155 mg, 1.0 mmole) and heated at reflux for 16 h. Diethyl ether (15 ml) was added to the reaction mixture, which was then extracted with water (2×), dried (MgSO4) and concentrated. Purification using a chromatotron, eluting with 10% EtOAc/hex (ethylacetate and hexane) provided 22 mg of the title compound. GC/MS: 251 (M/Z for C13H14ClNO2).

出典