反応 #2328976

反応方程式

hydrochloric acid

lithium aluminum hydride

methyl trans-4-vinylcyclohexanecarboxylate

water

→

(trans-4-vinylcyclohexyl)methanol

溶媒

THF

THF

反応条件

後処理

1. 1
   workup.ADDITIONthe resulting solution was added dropwise at 15 to 16° C. over 40 minutes
2. 2
   その他a sludge-like insoluble was removed by decantation
3. 3
   洗浄the resulting organic layer was washed with in turn with 10% hydrochloric acid
4. 4
   乾燥The organic layer was dried over anhydrous magnesium sulfate
5. 5
   濃縮concentrated

実験手順

5.7 g of lithium aluminum hydride was dispersed in 50 mL of THF and all of methyl trans-4-vinylcyclohexanecarboxylate was dissolved in 75 mL of THF and then the resulting solution was added dropwise at 15 to 16° C. over 40 minutes. After stirring at 10 to 20° C. for 30 minutes, water was slowly added. About 70 mL of 10% hydrochloric acid was added and a sludge-like insoluble was removed by decantation, and then the resulting organic layer was washed with in turn with 10% hydrochloric acid, a saturated sodium hydrogen carbonate solution, and saturated saline. The organic layer was dried over anhydrous magnesium sulfate and concentrated to obtain 26 g of (trans-4-vinylcyclohexyl)methanol.

出典