反応 #2328975

反応方程式

trans-4-vinyl cyclohexane carboxylic acid

trimethylsilyl chloride

→

methyl trans-4-vinylcyclohexanecarboxylate

溶媒

methanol

反応条件

後処理

1. 1
   温度by refluxing for 6 hours
2. 2
   濃縮concentrated under reduced pressure
3. 3
   workup.ADDITION150 mL of hexane was added
4. 4
   その他the methanol layer was separated
5. 5
   抽出the methanol layer was extracted with hexane
6. 6
   洗浄the mixture was washed with saturated saline
7. 7
   乾燥The organic layer was dried over anhydrous sodium sulfate
8. 8
   濃縮concentrated

実験手順

All of trans-4-vinyl cyclohexane carboxylic acid was dissolved in 120 mL of methanol and 0.1 g of trimethylsilyl chloride was added, followed by refluxing for 6 hours. The solution was cooling to room temperature and then concentrated under reduced pressure. 150 mL of hexane was added and the methanol layer was separated, and then the methanol layer was extracted with hexane. After combining with the organic layer, the mixture was washed with saturated saline. The organic layer was dried over anhydrous sodium sulfate and then concentrated to obtain 29.5 g of methyl trans-4-vinylcyclohexanecarboxylate.

出典