反応 #2324

反応方程式

Water

Acetyl chloride

4-amino1-benzylpiperidine

triethylamine

→

4-acetylamino-1-benzylpiperidine

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他to reach ambient temperature
2. 2
   その他the organic phase separated
3. 3
   その他dried
4. 4
   その他(MgSO4), and removal of the solvent
5. 5
   その他by evaporation

実験手順

Acetyl chloride (3.95 ml) was added dropwise to a stirred solution of 4-amino1-benzylpiperidine (10.0 g) and triethylamine (7.7 ml) in dry dichloromethane (100 ml) at 4° C. The mixture was allowed to reach ambient temperature and stirred for 16 hours. Water was then added, the organic phase separated and dried (MgSO4), and removal of the solvent by evaporation gave 4-acetylamino-1-benzylpiperidine, 10.23 g, as a light brown solid which was used without further purification: NMR (CDCl3) δ 7.29(5H,m), 5.29(1H,b), 3.79(1H,m), 3.49(2H,s), 2.80(2H,dm), 2.12(2H,dt), 1.95(3H,s), 191(2H,dm), 1.46(2H,dq); m/e 233 (M+H)+.

出典