反応 #2321810

反応方程式

sodium bicarbonate

3-(2-methoxy-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

2-amino-3-chloro-5-iodo-benzoic acid

→

2-amino-3-chloro-5-[3-(2-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid

収率 99.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The vial was sealed
2. 2
   その他purged with nitrogen
3. 3
   その他evacuated with vacuum (3×)
4. 4
   その他The vial was irradiated in a microwave at 90° C. for 400 seconds
5. 5
   抽出The aqueous layer was extracted three times with ethyl acetate
6. 6
   乾燥the combined organic phases were dried over sodium sulfate
7. 7
   その他evaporated
8. 8
   その他The resulting residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate (containing 10% methanol) and hexanes
9. 9
   濃縮The clean fractions were concentrated
10. 10
    その他the material was triturated with ether

実験手順

400 mg (0.793 mmol) of 3-(2-methoxy-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine, 32 mg (0.040 mmol) of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct and 259 mg (0.872 mmol) of 2-amino-3-chloro-5-iodo-benzoic acid were placed in a microwave vial. To the vial was added 3 mL of acetonitrile and 2 mL of a saturated aqueous solution of sodium bicarbonate. The vial was sealed and purged with nitrogen and evacuated with vacuum (3×). The vial was irradiated in a microwave at 90° C. for 400 seconds. The resulting mixture was distributed between ethyl acetate and brine. The aqueous layer was extracted three times with ethyl acetate and the combined organic phases were dried over sodium sulfate and evaporated. The resulting residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate (containing 10% methanol) and hexanes. The clean fractions were concentrated and then the material was triturated with ether to afford 430 mg (0.785 mmol, 51% yield) of 2-amino-3-chloro-5-[3-(2-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid as an orange solid. 1H NMR (500 MHz, CD3OD) δ 8.47 (d, 1H), 8.03 (m, 3H), 7.94 (d, 1H), 7.89 (s, 1H), 7.65 (d, 1H), 7.46 (dd, 1H), 7.34 (m, 3H), 7.09 (d, 1H), 7.02 (t, 1H), 3.82 (s, 3H), 2.33 (s, 3H); MS: m/z 547.9 (M+H+).

出典