反応 #2319221

反応方程式

hydrochloric acid

1-(2-aminosulfonylphenyl)-5-methyl-1H-tetrazole

phenyl N-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

desired product

収率 80.2%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-(5-methyl-1H-tetrazol-1-yl)benzenesulfonamide

収率 80.2%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The precipitate thus obtained
2. 2
   ろ過was filtered
3. 3
   洗浄washed with water
4. 4
   その他dried in vacuo

実験手順

To 0.48 g of 1-(2-aminosulfonylphenyl)-5-methyl-1H-tetrazole and 0.52 g of phenyl N-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate in 25 mL of acetonitrile at ambient temperature and pressure was added 0.3 mL of DBU. The mixture was stirred for three hours and then added to 25 g of ice and acidified with hydrochloric acid. The precipitate thus obtained was filtered, washed with water and dried in vacuo to yield 0.65 g of the desired product melting at 207°-209° C. Infrared absorption spectra showed absorption at 1700, 1600 and 1550 cm-1, consistent for the desired structure.

出典