反応 #2314293

反応方程式

alcohol

4-Methyl-3-cyclohexenol

p-toluenesulfonyl chloride

HCl

→

4-Methyl-3-cyclohexenol tosylate

溶媒

pyridine

反応条件

後処理

1. 1
   workup.WAITto stand at −20° C. for a further 16 hours
2. 2
   抽出extracted with ethyl acetate
3. 3
   抽出The combined organic layers are extracted with brine
4. 4
   乾燥dried over sodium sulfate
5. 5
   その他The solvent is removed in vacuo

実験手順

To a solution of alcohol 4C (R=methyl) (10 g) and p-toluenesulfonyl chloride (20.8 g) in anhydrous tetrahydrofaran (21 mL) at 0° C. is added anhydrous pyridine (21 mL). The reaction is allowed to stir in an ice bath for 2 hours, and is then allowed to stand at −20° C. for a further 16 hours. The reaction mixture is then poured into 2M HCl (75 mL) and extracted with ethyl acetate. The combined organic layers are extracted with brine and dried over sodium sulfate. The solvent is removed in vacuo.

出典