反応 #2314288

反応方程式

potassium carbonate

1-(4′-hydroxyphenyl)-3-bromopropane

dihydropyran

→

1-(4′-(2-tetrahydropyranyloxy)phenyl)-3-bromopropane

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度to warm to room temperature
2. 2
   ろ過The solid is then filtered out
3. 3
   その他the solvents and residual DHP is removed in vacuo

実験手順

To a solution of 1-(4′-hydroxyphenyl)-3-bromopropane 3B (3.56 g) in dichloromethane (11 mL) is added dihydropyran (2.3 mL). The reaction mixture is cooled to 0° C., and three drops of phosphorus oxychloride are added. The reaction mixture is stirred in the ice bath for a further two hours, then gradually allowed to warm to room temperature, where it is allowed to stir overnight. To the reaction mixture is then added potassium carbonate (3 g), and the reaction mixture is stirred an additional hour. The solid is then filtered out, and the solvents and residual DHP is removed in vacuo.

出典