反応 #2314286

反応方程式

HCl

phenol

4-[2-(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)ethyl]phenol

tosylate

cesium carbonate

→

4-[2-(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)ethyl]-1-(4-pentyl-3-cyclohexenyl)methoxybenzene

溶媒

dimethylforrnamide

反応条件

後処理

1. 1
   その他To a round-bottom flask equipped with a stirbar
2. 2
   抽出extracted with 1:1 hexanes
3. 3
   洗浄The combined organic layers are washed with brine
4. 4
   乾燥dried over potassium carbonate
5. 5
   濃縮the solution is concentrated in vacuo
6. 6
   ろ過Filtration through silica gel using 10% ethyl acetate in hexanes
7. 7
   その他gives the pure product

実験手順

To a round-bottom flask equipped with a stirbar is added phenol 2G (R=4-Methyl-3-pentenyl) (5 g), tosylate 1H (R=n-pentyl) (5.95 g), cesium carbonate (7.45 g), and anhydrous dimethylforrnamide (50 mL). The reaction mixture is stirred overnight. It is then poured into 50 mL dilute HCl, and extracted with 1:1 hexanes:ethyl acetate. The combined organic layers are washed with brine and dried over potassium carbonate, and the solution is concentrated in vacuo. Filtration through silica gel using 10% ethyl acetate in hexanes gives the pure product.

出典