反応 #2314281

反応方程式

hydrochloric acid

sodium hydroxide

nitrile

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

water

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

溶媒

hydrogen peroxide

反応条件

後処理

1. 1
   温度at reflux overnight
2. 2
   抽出The acid product is extracted with ethyl acetate
3. 3
   洗浄the combined organic layers are washed with brine
4. 4
   乾燥dried over magnesium sulfate
5. 5
   濃縮The solution is concentrated in vacuo

実験手順

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

出典