反応 #2314280

反応方程式

water

tosylate

potassium cyanide

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

溶媒

dimethylsulfoxide

反応条件

後処理

1. 1
   温度The reaction mixture is cooled to room temperature
2. 2
   抽出extracted with hexane
3. 3
   乾燥The combined organic layers are dried over magnesium sulfate
4. 4
   濃縮the solution is concentrated in vacuo

実験手順

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

出典