反応 #2307973

反応方程式

Triethylamine

ethyl 6-hydroxyhexanoate

methanesulfonyl chloride

→

compound 2

収率 85.3%

Ethyl 6-methylsulfonyloxyhexanoate

収率 85.3%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   ろ過The mixture was filtered through silica gel
2. 2
   洗浄the filtrate was washed successively with water, saturated NaHCO3, water and brine
3. 3
   乾燥The organics were dried over Na2SO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo to a pale yellow oil
6. 6
   その他Final purification of the crude product

実験手順

A solution of monodispersed ethyl 6-hydroxyhexanoate (50.76 ml, 50.41 g, 227 mmol) in dry dichloromethane (75 ml) was chilled in an ice bath and placed under a nitrogen atmosphere. Triethylamine (34.43 ml, 24.99 g, 247 mmol) was added. A solution of methanesulfonyl chloride (19.15 ml, 28.3 g, 247 mmol) in dry dichloromethane (75 ml) was added dropwise from an addition funnel. The mixture was stirred for three and one half hours, slowly being allowed to come to room temperature as the ice bath melted. The mixture was filtered through silica gel, and the filtrate was washed successively with water, saturated NaHCO3, water and brine. The organics were dried over Na2SO4, filtered and concentrated in vacuo to a pale yellow oil. Final purification of the crude product was achieved by flash chromatography (silica gel, 1/1 hexanes/ethyl acetate) to give the monodispersed compound 2 (46.13 g, 85%) as a clear, colorless oil. FAB MS: m/e 239 (M+H), 193 (M—C2H5O).

出典