反応 #2307967

ord-84004a01edaa4803a8018f5eaee77331

反応方程式

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid
→
CCCCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine Stearic Acid

反応物

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    ろ過sieved through a 120-mesh screen
  2. 2
    その他to obtain particles

実験手順

Equal amounts of Buprenorphine particles (prepared as described in Example 4) above) and stearic acid (prepared as described in Example 3) were blended and ground. The ground material was compressed in a 13-mm round die, with a force of 5,000 pounds for 5 minutes. Compressed tablets were ground and sieved through a 120-mesh screen followed by a 230-mesh screen to obtain particles having a size range between 63-125 microns.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07368126B2uspto-grants-2008_05