反応 #2304288

反応方程式

ethyl 4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoate

sodium hydroxide

hydrochloric acid

→

4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoic acid

収率 82.5%

溶媒

water

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   乾燥The organic layer was dried with anhydrous magnesium sulfate
3. 3
   その他The solvent was evaporated away

実験手順

A reaction mixture comprising 83 g of ethyl 4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoate, 12 g of sodium hydroxide, 50 ml of water and 200 ml of Solmix (registered trade mark) was refluxed for 2 hours. This was made acidic with hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate. The solvent was evaporated away, and 63 g of 4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoic acid (OX1) was obtained. m.p.: 58.5° C.

出典