反応 #2304

反応方程式

product

4-[4-(4-pyridyl)-piperazin-1-yl]anisole

water

ammonia

→

4-[4-(4-pyridyl)piperazin-1-yl]phenol

収率 95.6%

溶媒

hydrobromic acid

反応条件

後処理

1. 1
   温度The solution was cooled
2. 2
   ろ過The precipitate was filtered
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

The product from step (i) (1.5 g) in concentrated hydrobromic acid (30 ml) was heated under argon at 130°-135° C. for 21/2 hours. The solution was cooled, poured into water (150 ml) and basified with aqueous ammonia. The precipitate was filtered, washed with water and dried to give 4-[4-(4-pyridyl)piperazin-1-yl]phenol (1.36 g) as a solid: m.p. 310°-312° C.; NMR(d6DMSO) δ 8.2(2H,d); 6.8(4H,m); 6.66(2H,d); 3.45(4H,m); 3.08(4H,m).

出典