反応 #2301439

反応方程式

compound

2-Trityloxycarbamoyl-ethyl-succinic acid 4-tert-butyl ester 1-methyl ester

sodium hydroxide

→

2-(2-Trityloxycarbamoyl-ethyl)-succinic acid 4-tert-butyl ester

溶媒

methanol water

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the residue was partitioned between water and ether
3. 3
   抽出extracted with ethyl acetate
4. 4
   乾燥by drying over sodium sulfate, filtration and evaporation

実験手順

To a solution of the compound of example 65 (2.27 g, 4.39 mmol) in a mixture of methanol/water (4:1, 50 mL) was added a solution of sodium hydroxide (1N, 9 mL). The resulting mixture was stirred for 24 h at room temperature. The solvent was evaporated and the residue was partitioned between water and ether. The alkaline phase acidified using HCl (6N) and extracted with ethyl acetate followed by drying over sodium sulfate, filtration and evaporation. The product was converted to an off-white foam under high vacuum. 1H-NMR(CDCl3, 400 MH: 1.42(s, 9H); 1.59(m, 3H); 1.88–2.54(m, 4H); 7.33(m, 15H); 7.46(s, broad, 1H).

出典