反応 #2298662

反応方程式

6-fluoro-3-(4-piperidinyl)-1H-indazole

K2CO3

1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone

acetonitrile

→

desired product

収率 80.8%

1-[4-[3-[4-(6-Fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

収率 80.8%

溶媒

water

反応条件

後処理

1. 1
   温度was refluxed for 16 hours
2. 2
   その他the resulting white solid, which precipitated from solution
3. 3
   その他was collected

実験手順

A stirred mixture of 6-fluoro-3-(4-piperidinyl)-1H-indazole (3.5 g, 0.016 mol), K2CO3 (2.2 g), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (3.8 g, 0.016 mol) and acetonitrile (90 ml) was refluxed for 16 hours. The reaction was poured into water and the resulting white solid, which precipitated from solution, was collected to afford 5.5 g of the desired product. The compound was recrystallized from dimethylformamide (twice) to afford 3.0 g (44%) of 1-[4-[3-[4-(6-fluoro-1H-indazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone as a white solid, m.p.=202°-204° C.

出典