反応 #2298644

反応方程式

4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene

hydrogen

→

title compound

収率 70.0%

4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]aniline

収率 70.0%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   ろ過The mixture was filtered through a bed of celite
2. 2
   洗浄washed with dioxane
3. 3
   その他evaporated to dryness under reduced pressure

実験手順

A solution of 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene (1.0 g, 3.3 mmol) (obtained from preparation 20) in 1,4-dioxane (20 ml) was reduced with hydrogen in the presence of 10% palladium on charcoal (100 mg) at 30 psi for 16 h. The mixture was filtered through a bed of celite and washed with dioxane and evaporated to dryness under reduced pressure to yield the title compound (625 mg, 70%).

出典