反応 #2298641

反応方程式

4-[2-[2-ethyl-4-methyl-6-oxo-1,6dihydro-1-pyrimidinyl]ethoxy]benzyl hydroxylamine

KOCN

→

compound

収率 85.2%

N-[4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]benzyl]N-hydroxyurea

収率 85.2%

溶媒

water

acetic acid

water

water

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate (3×10 ml)
2. 2
   洗浄The combined organic layers were washed with brine
3. 3
   乾燥dried over anhydrous Na2SO4
4. 4
   濃縮concentrated

実験手順

To a stirred solution of 4-[2-[2-ethyl-4-methyl-6-oxo-1,6dihydro-1-pyrimidinyl]ethoxy]benzyl hydroxylamine (303 mg, 1.0 mmol) (obtained from preparation 18) in a mixture of water (2 ml) and acetic acid (0.5 ml) was added a solution of KOCN (343 mg, 3.0 mmol) in water (1 ml) and stirred for 1 h at 30° C. The reaction mixture was diluted with water and extracted with ethyl acetate (3×10 ml). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated to yield the compound (295 mg, 85%).

出典